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Dharma: Appendicitis Model

Dharma is a novel, interpretable machine learning based clinical decision support system, designed to address the diagnostic and prognostic challenges of pediatric appendicitis by integrating easily obtainable clinical, laboratory, and radiological data into a unified, real-time predictive framework.

SHAP Explanations:
The model uses SHAP (SHapley Additive exPlanations) values to interpret predictions. Each SHAP value quantifies the contribution of a specific input feature to the model’s output, relative to a base value. The base value represents the model’s expected output, and the sum of the SHAP values shows how much each feature pushes the prediction above or below this baseline.

Note: Input 0 if the value is not available or not applicable.

To be used by healthcare professionals only.

LITERATURE: doi: 10.1101/2025.05.27.25328468
EXPLORE Dharma: GitHub Repository Link

PERFORMANCE METRICS:
Threshold: 64%
AUC-ROC: 0.97-0.98
Sensitivity: 89%-95%
Specificity: 88%-98%
Positive Predictive Value: 93%-99%
Negative Predictive Value: 86%-91%

If appendix not visualized or USG unavailable:
AUC-ROC: 0.95
Threshold: 47% | High Likelihood
Specificity: 97% | PPV: 90%
Threshold: 37% | Probable
Specificity: 92% | NPV: 93%
Threshold: 30% | Possible
Sensitivity: 92%
Less than 30%: Low Likelihood
NPV: 95%
For Complications Prediction:
Sensitivity: 96% | NPV: 98%

Conceptualized, Designed, and Developed by:
Dr. Anup Thapa, MBBS
Founder: DharmaAI

Sincere gratitude to the team of DharmaAI and my dear friends:

Er. Subash Pahari: Web-app Development and Deployment
Thank you for introducing me to the wonders of coding and AI, and for your invaluable mentorship and support.
You are not just a great friend, but also a guiding force in this project.

Mr. Amrit Neupane: Logo Design | UI/UX Design

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Prediction Explanation